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5-Nitroimidazole derivatives: A scope of Modification for Medicinal chemists

Author Affiliations

  • 1Department of chemistry, H.N.B. Garhwal University, Srinagar Garhwal, Uttarakhand, INDIA
  • 2Department of Chemistry, University of Delhi, Delhi, INDIA

Res.J.chem.sci., Volume 3, Issue (7), Pages 104-113, July,18 (2013)


The 5-nitroimidazole is an important class of imidazole based drugs. The 5-nitroimidazoles are a well-established group of protozoal and bactericidal agents but after discovery of imidazole drugs many protozoa and bacteria has developed resistance towards drugs in market. Due to this fact there is a need for medicinal chemists to work on this pharmacophore and develop new hybrid molecules which may give lead molecule for further studies. Many modifications have been done on 5-nitroimidazole nucleus and new hybrid molecules have been synthesized but still there is a huge scope of modification. The imidazole moiety exhibit wide range of biological activities. This article aims to review the work done in past few years, on 5-nitroimidazoles derivatives synthesis and activity of resulting hybrid molecules.


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