International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 3 12 2013 December 18 Studies on DNA Cleavage and Antimicrobial screening of Transition Metal complexes of 4-aminoantipyrine Schiff base 22 28 EN Mohammed MahmudImam 1 Department of Applied Science, College of Science and Technology, Kaduna Polytechnic, NIGERIA Jimoh W.L.O 2 Department of Pure and Industrial Chemistry, Bayero University, Kano, NIGERIA Hamouda AbdElRahmanMA 1 Department of Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, EGYPT Nabih EnasSamir 2 Khalek SherihanAdelAbdEl 3 Patil Pragya 1 Central Institute of Mining and Fuel Research, Nagpur Unit, 17/C-Telenkhedi area civil lines, Mah, Nagpur, INDIA Singh Sripal 2 Rashtrasant Tukadoji Maharaj Nagpur University, Chhatrapati Shivaji Maharaj Administrative Premises, Ravindranath Tagore Marg, Mah, Nagpur 440001, INDIA Yenkie Maheshkumar 3 Shakya P.R. 1 Department of Chemistry, Faculty of Science, Padma Kanya Multiple Campus, Tribhuvan University, Bagbazar, Kathmandu, NEPAL Manjula B. 1 PG and Research Department of Chemistry, Presidency College, Chennai–600 005, Tamil Nadu, INDIA S. ArulAntony 2 S. ArulAntony 3 > Research Paper 2013 11 18 2013 December 18 The coordination compounds using Co(II), Ni(II), Cu(II) and Zn(II) ions with Schiff base ligand derived from furfurilydene-4-aminoantipyrine with o-anisidine in a 1:1 molar ratio have been synthesized and characterised by elemental analysis, IR, NMR and electronic spectral studies. On the basis of spectral studies, octahedral geometry is suggested for Co(II), Ni(II), Cu(II) and tetrahedral geometry for Zn(II) complexes. The synthesized ligand and metal(II) complexes have been tested against bacterial speciesPseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and fungal species Aspergillus niger (A. niger), Aspergillus fumigatus (A. fumigatus) and Candida albicans (C. albicans)in order to assess their antimicrobial properties. The results show that the metal complexes were more active than the ligand. The DNA cleavage activity of the ligand and its complexes were assayed using PUCI8 DNA by gel electrophoresis. The result shows that complete cleavage of DNA was observed in Cu(II) and Zn(II) complexes and partial cleavage of DNA was observed in Co(II) and Ni((II) complexes. Copyright@ International Science Community Association