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In-vitro Antioxidant activity of Diethyl malonate adducts of Phenothiazine

Author Affiliations

  • 1Department of Chemistry, Karpagam University, Coimbatore 641021, Tamil Nadu, INDIA

Res.J.chem.sci., Volume 3, Issue (1), Pages 82-85, January,18 (2013)


A series of novel diethyl malonate adducts 2a-g was prepared by the condensation between chalcones 1a-g and diethyl malonate in presence of KOt-Bu. The products were characterized by their spectral data (UV, IR, NMR and elemental analysis). In-vitro antioxidant activity was carried out for 2a-g which showed good anti-oxidant activity with IC50 value between 36.15 to 81.00g/ml and comparable to the control quercetin with IC50 value 44.53(g/ml). Compound 2a and 2d showed higher activity with IC50 value of 39.13 and 36.1g/ml respectively


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