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Antinociceptive and Antiinflammatory Effects of the Methanolic extract of Oscillatoria annae

Author Affiliations

  • 1Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Erode-638 052, Tamil Nadu, INDIA
  • 2Department of Microbiology, Bharathidasan University, Trichy, Tamil Nadu, INDIA
  • 3Department of Pharmacology, J.K.K. Nataraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, INDIA

Res.J.chem.sci., Volume 2, Issue (7), Pages 53-61, July,18 (2012)


The present study was designed to investigate antiinflammatory and antinociceptive activities of Oscillatoria annae. The antiinflammatory activity were studied in both acute and chronic inflammation models, where as by using four different animal models were employed to evaluate the antinociceptive activity of the extract in the acute model, carrageenan, dextran, histamine and serotonin were used to induce the inflammation in rat hind paw and cotton pellet enhanced granuloma method was used for chronic inflammation model. Acetic acid-induced writhing method, hot plate method, tail flick response and tail immersion method were used to evaluate the antinociceptive effect of the extract. The methanolic extract of Oscillatoria annae exhibited significant dose-dependent activity on the tested experimental animal models, and also on the extract significantly reduced in the acetic acid-induced abdominal contractions and the increased reaction time of mice in hot plate method, tail flick response and tail immersion method. This study has shown that the methanolic extract from the Oscillatoria annae does possess significant antiinflammatory and antinociceptive activity in animal models at the doses tested and the results were comparable to those observed for the standard drugs indomethacin, acetyl salicylic acid and morphine.


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