International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 2 1 2012 January 18 Chemical Examination and Biological Studies on the Seeds of Psoralea Corylifolia Linn. 50 58 EN Matini L. 1 Department of Exact Sciences, E.N.S, University Marien Ngouabi, B.P 69 Brazzaville, CONGO Tathy C. 2 Moutou J.M. 3 BaroteMaqbul A. 1 Department of Physics, Azad college, Ausa-413520, Maharashtra, INDIA YadavAbhijit A. 2 Thin Film Research Laboratory, Department of Physics, Rajarshi Shahu Mahavidyalaya, Latur-413512, Maharashtra, INDIA SurywanshiRangrao V. 3 Thin film and Solar Studies Research Lab, Dept. of Physics, Solapur University, Solapur-413 003, Maharashtra, INDIA DeshmukhLalasaheb P. 4 MasumdarElahipasha U. 5 Okonkwo S.I 1 Anambra State University Uli, Department of Chemistry, Anambra State, NIGERIA Ogbuneke R.U. 2 Alvan Ikoku Federal College of Education, Department of Chemistry, Imo State, NIGERIA Uyo B.K. 3 Federal University of Technology Owerri, Department of Chemical Engineering, Imo State, NIGERIA Deshpande S.M. 1 Post Graduate Department of Geology, Institute of Science, Caves Road, Aurangabad-431004, MH, INDIA Aher K.R. 2 Pawar M.J. 1 Laboratory of Materials Synthesis, Department of Chemistry, ACS College, Amravati, INDIA Nimbalkar V.B. 2 Medjor O.W. 1 Department of Chemistry, Taraba State University, Jalingo, NIGERIA Egharevba F. 2 Department of Chemistry, Ambrose Alli University, Ekpoma, NIGERIA Akpoveta O.V. 3 Ize-lyamu O.K. 4 Jatto E.O. 5 Mrinalini L. 1 Department of Chemistry, Manipur University, Canchipur, 795003, Imphal, INDIA Singh A.K.Manihar 2 Rao G.V. 1 Cavin Kare Research Centre, 12, Poonamalle Road, Ekkattuthangal Chennai 60032, INDIA Annamalai T. 2 Kavitha K. 3 Mukhopadhyay T. 4 > Research Paper 2011 10 31 2012 January 18 The aim of the present investigation was to isolate chemical constituents and study of its biological activity from the seeds of acetone extract of Psoralea corylifolia Linn. The bio-assay guided isolation of acetone extract of seeds yielded five known compounds, -cadinene (1), bakuchiol (2), psoralen (3), isopsoralen (4) and psoralidin (5). The structures of these compounds were elucidated by physical and spectral data (UV, IR, H, 13C NMR and mass). The compound, -cadinene (1) is first report from this plant. Different extracts, fractions and compounds from the seeds were investigated for antimicrobial property. The methanolic, acetone and hexane extracts and isolated compound, bakuchiol (2) of Psoralea corylifolia were tested for antimicrobial studies against three gram positive bacteria and showed positive results. The compound bakuchiol (2) showed an excellent antibacterial activity than its crude extract. Copyright@ International Science Community Association