International Science Community Association Research Journal of Chemical Sciences 16 2 2026 06 18 Sustainable synthesis and Physicochemical study of fused Pyrimidones by using Natural catalyst 53 56 EN Gupta Swaroopa Rani N. 1 Department of Chemistry, Brijlal Biyani Science College, Amravati, Maharashtra India Chaudhari Harshida G. 1 Department of Chemistry, Shree Jayendrapuri Arts and Science College, Bharuch, Gujarat, India Vashi Rajendra T. 2 Chemistry Department, Navyug Science College, Rander Road, Surat, Gujarat, India Sakhare D. T. 1 Department of Chemistry, Shivaji, Art’s, Comm. & Science College Kannad. Dist. Chhatrapti Sambhajinagar-431103, MS, India Gupta Swaroopa Rani N. 1 Department of Chemistry, Brijlal Biyani Science College, Amravati, Maharashtra, India Hicham Abbas Cheick 1 Doctoral School of Science, Technology and Sustainable Agriculture (ED-STAD), 01 BPV 34 Abidjan, Côte d'Ivoire and Laboratory of Reaction and Constitution of Matter (LCRM), UFR SSMT, Félix Houphouët-Boigny University, 22 BP 582 Abidjan 22, Côte d'Ivoire Konan Yao Marcel 2 Laboratory of Reaction and Constitution of Matter (LCRM), UFR SSMT, Félix Houphouët-Boigny University, 22 BP 582 Abidjan 22, Côte d'Ivoire Soumahoro Sangaré Naminata 3 Doctoral School of Science, Technology and Sustainable Agriculture (ED-STAD), 01 BPV 34 Abidjan, Côte d'Ivoire Arthur Konan Kouadio Fabrice 4 Laboratory of Reaction and Constitution of Matter (LCRM), UFR SSMT, Félix Houphouët-Boigny University, 22 BP 582 Abidjan 22, Côte d'Ivoire Jean-Claude Drida Bi Bénié 5 Doctoral School of Science, Technology and Sustainable Agriculture (ED-STAD), 01 BPV 34 Abidjan, Côte d'Ivoire and Laboratory of Reaction and Constitution of Matter (LCRM), UFR SSMT, Félix Houphouët-Boigny University, 22 BP 582 Abidjan 22, Côte d'Ivoire Qureshi Aqeela Abdul S. 1 Chemistry Department, Royal College of Arts, Science and Commerce (Autonomous), Mira Road (East), Dist. Thane 401107, Maharashtra, India Abbas Mustaqeem Mohammed 2 Chemistry Department, Royal College of Arts, Science and Commerce (Autonomous), Mira Road (East), Dist. Thane 401107, Maharashtra, India > Research Paper 2026 3 18 2026 06 18 Pyrimidone derivatives have been synthesized by grinding 1,3-Diketone heterocycle, Aromatic Aldehyde and Urea/Thiourea with catalytic amount of Fresh limejuice as a natural catalyst. The comparative physiochemical studies were done with respect to the reaction conversion, purity, atom economy, simplicity of reaction and easy work-up of the multicomponent reaction. The actual structures of all the products confirmed by different chemical test along with Chromatographic analysis, melting point and spectral technique like IR, 1H NMR and 13C NMR. Copyright@ International Science Community Association