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Synthesis, characterization, molecular docking and antibacterial evaluation of 3-aryl-1- phenyl-1H-pyrazole- 4-carbaldehyde-acylhydrazones

Author Affiliations

  • 1KLE’s S. Nijalingappa College, Rajajinagar, Bengaluru-10, India

Res.J.chem.sci., Volume 12, Issue (2), Pages 21-24, June,18 (2022)


In view of fostering research on efficacious antimicrobials, a series of new 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde acylhydrazones were synthesized in three steps commencing with the reaction of substituted acetophenones with phenyl hydrazine to yield respective Schiff bases. The respective formyl pyrazoles were synthesized from the Schiff bases by subjecting them to Vilsmeier-Haack formylation. The recrystallized formyl pyrazoles were then treated with substituted benzoic acid hydrazides in ethanol medium with acetic acid as the catalyst to obtain 3-Aryl-1-phenyl-1H-pyrazole-4-carbaldehyde acylhydrazones (4a-4e). The pyrazole derivatives were assessed for their effective inhibitory properties against bacterial DNA Gyrase B enzymes by molecular docking studies which were then evaluated for their in vitro antibacterial activities.


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