International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 1 2 2011 May 18 Chemical Constituents and Melanin Promotion activity of Cissus quadranglaris Linn 25 29 EN Manocha N. 1 Swami Vivekanand college of Pharmacy, Indore, INDIA Chandra S.K. 2 Suresh Gyan Vihar University, Jaipur, INDIA Sharma V. 3 B.M College of Pharmaceutical Sciences, Indore, INDIA Sangameswaran B. 4 Saluja M. 5 Sathyaraj A. 1 Swami Vivekanand college of Pharmacy, Indore, INDIA Satyanarayana V. 2 Suresh Gyan Vihar University, Jaipur, INDIA Rao M.V.Basaveswara 3 B.M College of Pharmaceutical Sciences, Indore, INDIA Pruthviraj R.D. 1 Dept. of Chemistry, Amruta Institute of Eng. and Mangt. Sci., Bidadi, Bangalore, INDIA Rao G.V. 1 CavinKare Research Centre, 12, Poonamalle Road, Ekkattuthangal, Chennai-600 032, INDIA Annamalai T. 2 Mukhopadhyay T. 3 Madhavi S 4 Machavolu Lakshmi 5 > Research Paper 2011 4 05 2011 May 18 Bio-activity guided isolation of the methanolic extract of the stems of Cissus quadrangularis Linn., resulted three known compounds, lupeol (1), freidalin (2) and -sitosterol (3). The structures of these compounds were elucidated by physical and spectral data (UV, IR, H, 13C NMR and Mass). Different fractions and compounds from the stems were investigated for melanin promotion activity. The compound, lupeol (3) showed five times more potent melanin promotion activity when compared with standard control compound, 3-isobutyl-1-methylxanthine (IBMX). Copyright@ International Science Community Association