International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 1 2 2011 May 18 Anti-Rheumatic and Antioxidant activity of extract of Stem bark of Ficus bengalensis 2 8 EN Manocha N. 1 Swami Vivekanand college of Pharmacy, Indore, INDIA Chandra S.K. 2 Suresh Gyan Vihar University, Jaipur, INDIA Sharma V. 3 B.M College of Pharmaceutical Sciences, Indore, INDIA Sangameswaran B. 4 Saluja M. 5 > Research Paper 2011 04 1 2011 May 18 Ficus bengalensis Linn (Moraceae) is commonly known as Banyan tree or Bargad. It possesses medicinal properties and in ayurveda is used in diuretic, hypoglycemic, anti-inflammatory agent and in diarechea. The analgesic, anti rheumatic and ant-oxidant activity of the methanolic extract of the bark of Ficus bengalensis (MFB) were studied at doses of 100, 200 and 300 mg/kg (i.p) using the Freund’s Complete Adjuvant induced arthritis model, the Formalin induced arthritis model and the Agar induced arthritis model. The extract produced marked inhibitory effect on edema especially on secondary immunological arthritis and caused graded inhibition of both phases of Formalin- induced pain .The present study validates the traditional use, demonstrating that the methanolic extract of bark of Ficus bengalensis possesses dose –dependent anti-rheumatic activity in all the models with a possibility of acting through the central and peripherally mediated activities. The DPPH and hydrogen peroxide model demonstrated positive antioxidant activity in a concentration dependent manner(100g/ml). Copyright@ International Science Community Association