<p><span style=\"background: white; color: black; line-height: 115%; font-family: \'Times New Roman\',\'serif\'; font-size: 12pt; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\">Dipyrromethanes are important precursors for the synthesis of various functional porphyrinoids, linear porphyrinoid arrays and expanded porphyrinoids. The condensation of aldehydes with excess of pyrrole in presence of different acids such as trifluoroacetic acid, BF<sub>3</sub>-etherate,<span class=\"apple-converted-space\">&nbsp;</span><em>p</em>-toluene sulphonic acid and acetic acid or metal triflates in organic solvents or in the absence of any other solvent yield meso-substituted dipyrromethanes along<span class=\"apple-converted-space\">&nbsp;</span>with oligomeric by-products. The major disadvantages of above methods are the requirement of large amounts of pyrrole, corrosive acidic catalyst and the use of chlorinated solvents. The organic reaction in aqueous solution is an important area of current research interests including green chemistry. The use of boric acid in aqueous solution has not been used in the synthesis of dipyrromethanes. Herein, we report the condensation of pyrrole with aldehydes using boric acid as catalyst in water to afford the corresponding dipyrromethanes in high yields. The present method is green and efficient for the synthesis of dipyrromethanes using only two equivalents of pyrrole and avoiding the use of chlorinated solvents as well as corrosive acidic catalyst.</span></p>