<p class=\"MsoNormal\" style=\"text-align: center;\" align=\"center\"><strong><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',\'serif\';\">&nbsp;</span></strong></p>
<p class=\"MsoNormal\" style=\"text-align: justify; line-height: 150%;\"><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\">Isoxazoles are a class of heterocyclic compounds having a remarkable number of applications and have been demonstrated to be very versatile buildi</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">ng blocks in organic synthesis. </span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\">Isoxazol-5(<em>4H</em>)-ones compounds have attracted increasing interest due to their significant pharmaceutical and therapeutic properties, such as hypoglycemic, immunosuppressive, anti-inflammatory and anti-bacterial activities</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">.</span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\"><br /> </span><span style=\"font-family: \'Times New Roman\',\'serif\';\">In this proposed work, a</span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\"> highly efficient </span><span style=\"font-family: \'Times New Roman\',\'serif\';\">and environmentally benign </span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\">methodology for the synthesis of 3-methyl-4-arylmethylene-isoxazole-5(4H)-ones has been developed by reaction of aromati</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">c aldehydes, ethyl acetoacetate</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">and </span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\">hydroxylamine h</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">ydrochloride</span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\"> in aqueous ethanol in presence of CaCl<sub>2</sub>.2H<sub>2</sub>O.</span><span style=\"font-family: \'Times New Roman\',\'serif\';\"> The reaction mixture was </span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\">stirred on magnetic stirrer (300 rpm) at room tem</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">perature affording good</span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\"> quantitative yield. </span><span style=\"font-family: \'Times New Roman\',\'serif\';\">The reaction condition was further examined for the effective ratio of water: ethanol on the % yield of the product. </span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\">A numbe</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">r of structurally diverse aldehyde</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">was</span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\"> then screened for studying the generality as well as the efficiency of the procedure. </span><span style=\"font-family: \'Times New Roman\',\'serif\';\">Synthesized compounds were characterized by their I.R., <sup>1</sup>H-NMR spectra and melting point analysis.</span></p>
<p class=\"MsoNormal\" style=\"text-align: justify; line-height: 150%;\"><strong><span style=\"font-family: \'Times New Roman\',\'serif\';\">Keywords: </span></strong><span style=\"font-family: \'Times New Roman\',\'serif\';\">environmentally benign, </span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\">3-methyl-4-arylmethylene-isoxazole-5(4H)-ones</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">, </span><span style=\"font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Calibri;\">CaCl<sub>2</sub>.2H<sub>2</sub>O</span><span style=\"font-family: \'Times New Roman\',\'serif\';\">. </span></p>
 
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