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<p class=\"MsoNormal\" style=\"text-align: justify;\"><span class=\"bodytext\"><span style=\"font-family: \'Times New Roman\',\'serif\';\">Fast dissolving tablets are one type of solid dosage form that can dissolve and disintegrate quickly in the saliva without administering with water. It is very convenient to administer especially for geriatric and pediatric patients. It is convenient for patients who are travelling may face difficulty in access of water. Fast dissolving tablets can enhance the disintegration and dissolution rate, thereby increase the bioavailability and therapeutic effectiveness. The role of disintegrants in the design of fast dissolving drug delivery systems is discussed in this article. Superdisintegrants can be added in the formulation to enhance the rate of disintegration. It can decrease the disintegration time so can increase the dissolution rate. It can promote moisture penetration into the tablet matrix and cause dispersion of the tablet matrix. Swelling, wicking, deformation, repulsive force, heat wetting and enzymatic action are the mechanisms of action of superdisintegrants. Superdisintegrants can be classified into natural and synthetic. Examples for natural superdisintegrants are banana powder, soypolysaccharide etc. Examples for synthetic superdisintegrants are Sodium Starch Glycolate, Cross-linked polyvinyl pyrrolidone etc. Natural superdisintegrants are more widely used than synthetic superdisintegrants as they are more economical, low cost, easily available, non- toxic on the body and more patient compliance.</span></span></p>
<p class=\"MsoNormal\" style=\"text-align: justify;\"><span class=\"bodytext\"><span style=\"font-family: \'Times New Roman\',\'serif\';\"><span style=\"mso-spacerun: yes;\">&nbsp;</span>Key words: Fast Dissolving Tablets, Superdisintegrants, Classification, Mechanism, Disintegration.</span></span></p>