<p class=\"MsoNormal\" style=\"text-align: justify; text-justify: inter-ideograph; line-height: 200%;\"><span style=\"font-size: 12.0pt; line-height: 200%; font-family: \'Times New Roman\',\'serif\';\">Sleep plays very critical roles in physiological process and survival of individuals. Rapid eye movement sleep deprivation (REMSD), a crucial phase of sleep is essential for maintenance of body physiology of rats. REMSD induced apoptosis of </span><span style=\"font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: \'Times New Roman\',\'serif\';\">peripheral blood mononuclear cells</span><span style=\"font-size: 12.0pt; line-height: 200%; font-family: \'Times New Roman\',\'serif\';\"> (PBMC&rsquo;s) along with altered serum inflammatory marker enzymatic proteins like Super Oxide Dismutase (SOD), Lipid Peroxides (LPO) and non-enzymatic antioxidants like Glutathione (GSH). DNA laddering and TUNEL assay detected and confirmed the apoptotic bodies of PBMC&rsquo;s on 4<sup>th</sup> day (moderate loss) as well as on 9<sup>th</sup> day (acute loss) of REMSD. Our study showed that REMSD can cause apoptosis of PBMC&rsquo;s in rats while inducing oxidative damage in individuals.</span></p>