<p class=\"MsoNormal\" style=\"margin-bottom: 0.0001pt; text-align: justify;\"><em><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\';\">The textile industry is challenged by the presence of microorganisms and the negative effects they cause. Deterioration, defacement and odors are all dramatic effects that occur from the microbial contamination of woven, nonwoven, and composite fabrics.&nbsp; Health and hygiene are the primary requirements for human beings to live comfortably and work with maximum efficiency. To protect the mankind from pathogens and to avoid cross infection, a special finish like antimicrobial finish has become necessary. The major antimicrobial agents for textile coating are chemical agents which have toxic and environmental issues. Several natural dyes obtained from plants exhibit strong antimicrobial properties. Therefore, coating of antimicrobial plant natural dyes and bioactive plant extract on to cotton fabrics is an emerging technology in the production of medical cloths. The present investigation emphasizes on screening of herbs with potent antimicrobial activity, treatment of cotton fabric and SMS Nonwoven fabric with herbal leaf extracts, assessment of their antimicrobial efficacy. Based on the antimicrobial activity and availability Neem was selected</span></em><em><span style=\"font-family: \'Times New Roman\',\'serif\';\">.&nbsp;&nbsp;</span></em></p>