<p class=\"MsoNormal\" style=\"text-align: justify; line-height: 150%;\"><span style=\"font-family: \'Times New Roman\',\'serif\';\">The development of convenient and environmentally benign procedure with high productivity using non-toxic, low cost catalyst system under mild reaction conditions is the demanding research area in organic chemistry. Formamides are an important class of intermediates in the preparation of pharmaceuticals and have been widely used as amine protecting groups and as precursors to isocyanides and hetrocycles. In the present study formamide derivatives were synthesized in good yield with amines and formic acid employing 10 mol % of hydroxylamine hydrochloride as a powerful catalyst at room temperature under solvent free condition. The reaction condition was further optimized for minimum mole ratio of amine: formic acid. 1:2 mole ratio of amine: formic acid was found to be most effective affording high quantitative yield. Synthesized compounds were characterized by their I.R. and <sup>1</sup>H-NMR spectra. Some of these compounds were also screened for their antioxidant activity using </span><span style=\"font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',\'serif\';\">DPPH scavenging method.</span></p>
 
<p class=\"MsoNormal\" style=\"text-align: justify; line-height: 150%;\"><strong><span style=\"font-family: \'Times New Roman\',\'serif\';\">Keywords: </span></strong><span style=\"font-family: \'Times New Roman\',\'serif\';\">environmentally benign, formamide derivatives, hydroxylamine hydrochloride, antioxidant.</span></p>