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Coronavirus disease 2019: A clinical review

Author Affiliations

  • 1Independent Researcher, Burdwan-713104, West Bengal, India

Int. Res. J. Medical Sci., Volume 9, Issue (1), Pages 12-16, February,28 (2021)


Coronavirus Disease or COVID 19 is a public health emergency caused by SARS-CoV-2.The virus is causing a pandemic with death tolls increasing at an alarming rate. It is mainly a respiratory disease that affects also affects the other systems. The disease spreads via fomites and patient presents with common symptoms of cough and cold. In this review I have reviewed the epidemiology of the disease, virus taxonomy and properties, its infectivity and transmission, risk factors, case definitions and severity of disease, clinical presentations, investigations, laboratory findings, treatment and prevention.


  1. Reprint (2020)., Interim Guidance Clinical Management of COVID 19., released on 27 May 2020, retrieved from, Copyright CC BY-NC-SA 3.0 IGO
  2. WHO (2019)., Coronavirus disease 2019 (COVID-19) Situation Report - 61., 20/March/2020.
  3. Gorbalenya, A.E., Baker, S.C., Baric, R.S. et al. (2020)., , The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2.
  4. Lu, Roujian, Xiang Zhao, Juan Li, PeihuaNiu, Bo Yang, Honglong Wu, Wenling Wang et al. (2019)., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding., The Lancet, 395, 10224(2020), 565-574.
  5. Wan, Yushun, Jian Shang, Rachel Graham, Ralph S. Baric, and Fang Li. (2020)., Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus., Journal of virology, 94, no. 7.
  6. Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X. and Cheng, Z. (2020)., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China., The lancet, 395(10223), 497-506.
  7. Totura, A. L., & Baric, R. S. (2012)., SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon., Current opinion in virology, 2(3), 264-275.
  8. Li Q, Guan X, Wu P, et al. (2020)., Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia., N Engl J Med., oa2001316. [Epub ahead of print]
  9. Liu, Ying, Albert A. Gayle, Annelies Wilder-Smith, and Joacim Rocklöv (2020)., The reproductive number of COVID-19 is higher compared to SARS coronavirus., Journal of travel medicine, (2020).
  10. Jiang, F., Deng, L., Zhang, L., Cai, Y., Cheung, C.W. and Xia, Z. (2020)., Review of the clinical characteristics of coronavirus disease 2019 (COVID-19)., Journal of general internal medicine, 1-5.
  11. Chen H, Guo J, Wan C, et al. (2020)., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records., 30360-3.
  12. Chin, A., Chu, J., Perera, M., Hui, K., Yen, H. L., Chan, M., ... & Poon, L. (2020)., Stability of SARS-CoV-2 in different environmental conditions., MedRxiv.
  13. Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., ... & Feng, Z. (2020)., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia., New England journal of medicine.
  14. World Health Organization. (2020)., Global surveillance for human infection with novel coronavirus (2019-nCoV): interim guidance., 21 January 2020, No. WHO/2019-nCoV/SurveillanceGuidance/2020.1. World Health Organization.
  15. Zheng, Zhaohai, Fang Peng, BuyunXu, Jingjing Zhao, Huahua Liu, Jiahao Peng, Qingsong Li et al. (2020)., Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis., Journal of Infection.
  16. Jang, Youngeun, Hyo-Ju Son, Seungjae Lee, Eun Jung Lee, Tae Hyong Kim, and Se Yoon Park (2020)., Olfactory and taste disorder: the first and only sign in a patient with SARS-CoV-2 pneumonia., Infection Control & Hospital Epidemiology, 1-1. DOI: 51
  17. Lovato, A., & De Filippis, C. (2020)., Clinical presentation of COVID-19: a systematic review focusing on upper airway symptoms., Ear, Nose & Throat Journal, 99(9), 569-576.
  18. Zhu, J., Ji, P., Pang, J., Zhong, Z., Li, H., He, C., ... & Zhao, C. (2020)., Clinical characteristics of 3062 COVID‐19 patients: A meta‐analysis., Journal of medical virology, 92(10), 1902-1914.
  19. Rodriguez-Morales, A. J., Cardona-Ospina, J. A., Gutiérrez -Ocampo, E., Villamizar-Peña, R., Holguin-Rivera, Y., Escalera-Antezana, J. P., ... & Sah, R. (2020)., Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis., Travel medicine and infectious disease, 34, 1016-1023.
  20. Lechien, J. R., Chiesa-Estomba, C. M., De Siati, D. R., Horoi, M., Le Bon, S. D., Rodriguez, A., ... & Saussez, S. (2020)., Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): A multicenter European study., European Archives of Oto-Rhino-Laryngology, 277(8), 2251-2261.
  21. Kakodkar, P., Kaka, N., & Baig, M. N. (2020)., A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19)., Cureus, 12(4).
  22. Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., ... & Cao, B. (2020)., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China., The lancet, 395(10223), 497-506.
  23. Phan, Lan T., Thuong V. Nguyen, Quang C. Luong, Thinh V. Nguyen, Hieu T. Nguyen, Hung Q. Le, Thuc T. Nguyen, Thang M. Cao, and Quang D. Pham (2020)., Importation and human-to-human transmission of a novel coronavirus in Vietnam., New England Journal of Medicine, 382(9), 872-874.
  24. Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., ... & Hu, B. (2020)., Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China., JAMA neurology, 77(6), 683-690.
  25. Cepheid Xpert® xpress (2020)., SARS-CoV-2 has received FDA emergency use authorization., https://www., Accessed 12th Apr 2020
  26. News (2020)., Detect COVID-19 in as Little as 5 minutes Abbott Newsroom., corpnewsroom/product-and-innovation/detect-covid-19-in-as-little-as-5-minutes.html, Accessed 12th Apr 2020
  27. Tang N, Li D, Wang X and Sun Z. (2020)., Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia., J Thromb Haemost, 18(4), 844‐847. doi:10.1111/jth.14768
  28. Henry, B., de Oliveira, M., Benoit, S., Plebani, M., & Lippi, G. (2020)., Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): A meta-analysis, Clinical Chemistry and Laboratory Medicine., doi:
  29. Cai, Qingxian, Deliang Huang, Hong Yu, Zhibin Zhu, Zhang Xia, Yinan Su, Zhiwei Li et al. (2020)., COVID-19: abnormal liver function tests., Journal of hepatology.
  30. Guan, Wei-jie, Zheng-yi Ni, Yu Hu, Wen-hua Liang, Chun-quan Ou, Jian-xing He, Lei Liu et al. (2020)., Clinical characteristics of coronavirus disease 2019 in China., New England journal of medicine, 382(18), 1708-1720.
  31. Agostini, M. L., Andres, E. L., Sims, A. C., Graham, R. L., Sheahan, T. P., Lu, X., ... & Denison, M. R. (2018)., Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proof reading exoribonuclease., MBio, 9(2).
  32. Delang, Leen, RanaAbdelnabi, and Johan Neyts (2018)., Favipiravir as a potential countermeasure against neglected and emerging RNA viruses., Antiviral research, 153, 85-94.
  33. Koren, G., King, S., Knowles, S., & Phillips, E. (2003)., Ribavirin in the treatment of SARS: A new trick for an old drug?., Cmaj, 168(10), 1289-1292.
  34. Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., ... & Xiao, G. (2020)., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro., Cell research, 30(3), 269-271.
  35. Geleris, Joshua, Yifei Sun, Jonathan Platt, Jason Zucker, Matthew Baldwin, George Hripcsak, Angelena Labella et al. (2020)., Observational study of hydroxychloroquine in hospitalized patients with Covid-19., New England Journal of Medicine.
  36. Danser, AH Jan, Murray Epstein, and Daniel Batlle (2020)., Renin-angiotensin system blockers and the COVID-19 pandemic: at present there is no evidence to abandon renin-angiotensin system blockers., Hypertension, 75(6), 1382-1385
  37. Lim, Jaegyun, SeunghyunJeon, Hyun-Young Shin, Moon Jung Kim, Yu Min Seong, Wang Jun Lee, Kang-Won Choe, Yu Min Kang, Baeckseung Lee, and Sang-Joon Park (2020)., Case of the index patient who caused tertiary transmission of COVID-19 infection in Korea: the application of lopinavir/ritonavir for the treatment of COVID-19 infected pneumonia monitored by quantitative RT-PCR., Journal of Korean medical science, 35(6).
  38. Chen, C., Zhang, X. R., Ju, Z. Y., & He, W. F. (2020)., Advances in the research of cytokine storm mechanism induced by Corona Virus Disease 2019 and the corresponding immunotherapies. Zhonghua shao shang za zhi= Zhonghua shaoshang zazhi=., Chinese Journal of Burns, 36, E005-E005.
  39. Li L, Zhang W, Hu Y, et al. (2020)., Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial., JAMA, 324(5), 460-470. doi:10.1001/jama.2020.10044
  40. Infection Prevention and Control (2020)., Accessed 12th Apr 2020., undefined, undefined