International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Prevalence of Hepatitis C Virus Seropositivity among blood donors in a Tertiary care hospital

Author Affiliations

  • 1 Department of Immunohematology and Blood Transfusion, Dayanand Medical College and Hospital, Ludhiana, 141001, Punjab, INDIA

Int. Res. J. Medical Sci., Volume 3, Issue (2), Pages 22-24, February,28 (2015)


Hepatitis C Virus (HCV) is a major cause of post transfusion hepatitis. Seropositivity of HCV among blood donors varies from 0.53%-5.1% in different parts of India. The aim of study is to see the prevalence of anti HCV antibodies among healthy blood donors in Punjab. This retrospective analysis included blood donor screening data from January 2009 to December 2013 (5 years). Donor samples were screened for anti-HCV antibodies by ELISA using HCV UTRA HEPNOSTIKA KIT, Biomerieux, France. Analysisofseropositivity in replacement and voluntary blood donors were compared using the Pearson Chi-Square test. Of the total 1, 56,695 blood units screened, 1.45% (n=2286) were found to be reactive for anti HCV antibodies. The seropositivity of HCV varied from 1.13% to 1.74%. Out of the total blood donors’ positive for anti-HCV antibody, 68.8% were replacement and 31.2% were voluntary and statistically significant (p0.05). The screening of blood products is the only way for preventing the transfusion associated cases of hepatitis. The introduction of donor counseling, screening for different pathogens and donors self exclusion and ensuing a 100% voluntary blood donation will be effective in decreasing the hepatitis rate.


  1. Cooke G.S., Lemoini M., Thursz M., Gore C., Swan T. and Kamarulzaman A. et al., Viral hepatitis and the global burden of disease: a need to regroup, J. Viral. Hepat., 20, 600-1 (2013)
  2. Razavi H., Elkhoury A.C., Elbaasha E., Estes C., Pasini K. and Poynard T. et al., Chronic Hepatitis C virus (HCV) disease burden and cost in the United States, Hepatology, 57, 2164-70 (2013)
  3. Deshpande R.H. and Wadde S.K., Seroprevalence of HCV in blood donor status of blood donors seropositivity of HCV in Marathwada India, J. Pharm. Biomed. Sci.,23, 1-4 (2012)
  4. Jain A., Rana S.S., Chakravarty P., Gupta R., Murthy N.S. and Nath M.C. et al., The prevalence of hepatitis C virus antibodies among the voluntary blood donors of New Delhi, India, Eur. J. Epidemiol.,18, 695-7 (2003)
  5. Sood A.S.S., Midha V., Jyoti D., High seroprevalence of Hepatitis C virus and dual infection (Hepatitis B and C virus) in non-alcoholic chronic liver disease in North India, J. Assoc. Physicians India,47, 205-8 (1999)
  6. Esteban Juan I., Gonzalez A., Hernandez Jose M. and Viladomiu L. et al., Evaluation of antibodies to Hepatitis C Virus in a study of Transfusion Associated Hepatitis, N. Engl. J. Med.,323, 1107-12 (1990)
  7. Makroo R.N., Walia R., Chowdhry M., Bhatia A., Hegde V. and Rosama N.L., Seroprevalence of anti-HCV antibodies among blood donors of North India, Indian J. Med. Res, 138, 125-8 (2013)
  8. Bhawani Y., Rao P.R. and Sudhakar V., The seroprevalence of transfusion transmissible infection among the blood donors in a tertiary care hospital of Andhra Pradesh, Biology and Medicine, 45-8 (2010)
  9. Kaur H., Manjari M., Thaman R.G. and Singh G., Prevalence of Markers of Hepatitis C virus among the blood donors, J. Clin. Diag. Res., 959-62 (2012)
  10. Arankalle V.A., Chadha M.S., Jha J., Amrapurkar D.N. and Banerjee K., Prevalence of anti HCV antibodies in Western India, Indian J. Med. Res.,101, 91-3 (1995)
  11. Deshpande A., Kumar A., Khodaiji A. and Gupta A.D., Prevalence of hepatitis C virus antibody in healthy blood donors, Indian J. Hemat. Blood Tranf.,16, 71-2 (1998)
  12. Arora D., Arora B. and Khetarpal A., Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in southern Haryana, Indian J. Pathol. Microbiol., 53, 308-9 (2010)
  13. Panda M. and Kar K., HIV, hepatitis B and C infection status of the blood donors in a blood bank of a tertiary health care centre of Orissa, Indian J. Public Health,52, 43-4 (2008)
  14. Manzoor I., Hashmi N., Daud S., Ajmal S., Fatima H. and Rasheed Z. et al., Seroprevalence of transfusion transmissible infections (TTIs) in blood donors, Biomédica, 25, 154-8 (2009)
  15. Davis G.L., Albright J.E., Cook S.F. and Rosenberg D.M., Projecting future complications of chronic hepatitis C in the United States, Liver Transpl.,, 331-8 (2003)
  16. Shepard C.W., Finelli L., Alter M.J., Global epidemiology of hepatitis C virus infection, LancetInfect. Dis., 5(9),558-67(2005)
  17. Nanu A., Sharma S.P., Chatterjee K. and Jyoti P., Markers for transfusion transmissible infections in north Indian voluntary and replacement blood donors : Prevalence and trends 1989-1996, Vox Sang.,73, 70-3 (1997)