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Preliminary Phytochemical investigations and evaluation of Antimicrobial activity of n-hexane extract of the leaves of Synclisia scabrida family menispermaceae

Author Affiliations

  • 1 Dept of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, NIGERIA
  • 2 Dept of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, NIGERIA
  • 3 Dept of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, NIGERIA

Res. J. of Pharmaceutical Sci., Volume 2, Issue (3), Pages 1-5, May,30 (2013)


The leaves of Synclisia scabrida were claimed to have antimicrobial properties. The leaves were used to treat wounds, running stomach, as well as fever. This investigation was carried out to ascertain the veracity of the claim. The leaves were collected and dried at ambient temperature and pulverized. 250gm of the powdered drug was extracted with 0.5 litre of n-hexane using the cold maceration technique for 24hours with occasional shaking. This was filtered and the process repeated using the marc. The combined filtrates were concentrated under reduced pressure with rotary evaporator. The preliminary phytochemical test were carried out using standard methods. The antimicrobial activity was evaluated using agar diffusion method. The leaves of synclisia scabrida exhibited antimicrobial property. Alkaloid, flavonoids, saponins, terpenoids and glycosides were found. Conclusion the claim on the use of Synclisia sabrida appears to be obvious in line with the results of the investigation.


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