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Synthesis and Crystal structure studies of Diethyl-(6-chloro-2-carbazolyl) Methyl malonate an intermediate in the synthesis of Anti-inflammatory drug Carprofen

Author Affiliations

  • 1Dept of Chemistry, Manipal Institute of Technolgy, Manipal University, Manipal, Karnataka, INDIA
  • 2Department of Studies in Physics, University of Mysore, Mysore, INDIA
  • 3Dept of Biotechnology, Sri Jayachamarajendra College of Engineering, Mysore, INDIA

Res. J. of Pharmaceutical Sci., Volume 1, Issue (1), Pages 16-22, September,30 (2012)


Diethyl-(6-chloro-2-carbazolyl)methyl malonate, an intermediate in the synthesis of anti-inflammatory drug Carprofen and number of biologically active heterocycles, was synthesized and X-ray studies have been performed. The crystal structure analysis shows the title compound crystallizes in triclinic class under the space group P-1 with cell parameters, a = 9.3408(11) °A, b = 10.4853(12) °A, c = 11.1601(13) °A α= 113.623(6), β= 105.130(6), γ= 93.040(6) and Z=2. The molecule exhibits N-H-O type intermolecular hydrogen bond.


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