International Science Community Association Research Journal of Engineering Sciences 15 3 2026 09 26 Stimuli-Responsive Supramolecular Hydrogels in Precision Medicine: Recent Advances, Challenges, and Translational Perspectives 15 22 EN Amos Omboua Eyandzi 1 Laboratory of Electrical Engineering and Electronic, Polytechnic Superior National School, Marien Ngouabi University, Brazzaville, Congo Flory Lidinga Mobonda 2 Laboratory of Electrical Engineering, ISTA-Kinshasa, Democratic Republic of the Congo Timothée Nsongo 3 Faculty of Sciences and Techniques, Marien Ngouabi University, Brazzaville, Congo André Pasi Bengi Masata 4 Laboratory of Electrical Engineering, ISTA-Kinshasa, Democratic Republic of the Congo Jha Aashish 1 VIVA College, Virar, Palaghar, Maharashtra, India Vohra Shruti 1 Department of Engineering Sciences and Humanity, Chameli Devi Group of Institutions, Indore 452020, MP, India Verma Smita 2 Department of Applied Mathematics and Computational Science, SGSITS, Indore 452003, MP, India Rawat Mohan 3 Department of Engineering Sciences and Humanity, Chameli Devi Group of Institutions, Indore 452020, MP, India Chaturvedi Shreyansh 1 LNCT University, Bhopal, MP, India > Review Paper 2026 6 9 2026 09 26 Stimuli-responsive supramolecular hydrogels have emerged as a promising class of dynamic biomaterials with significant potential in advanced biomedical applications. These hydrogels are formed through reversible non-covalent interactions, enabling adaptive structural and functional responses to specific internal and external stimuli. Such responsiveness allows precise control over drug release, making them highly suitable for targeted drug delivery, cancer therapy, and tissue engineering. Recent advances in molecular design, hybrid nanocomposites, and multifunctional systems have further enhanced their performance and applicability in precision medicine. However, several challenges persist, including limitations in structural stability, concerns regarding biocompatibility, difficulties in large-scale manufacturing, and complex regulatory requirements. Addressing these issues is critical for successful clinical translation. Despite these challenges, the ability of these hydrogels to respond intelligently to biological cues and provide personalized therapeutic outcomes underscores their importance in next-generation healthcare. Their integration into precision medicine frameworks holds considerable promise for improving treatment efficacy, reducing side effects, and enabling more patient-specific therapeutic strategies. Copyright@ International Science Community Association