International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 1 2 2012 June 10 Structural Characterization of Histone Deacetylase from Plasmodium falciparum 65 68 EN Muhammad Jamshed Khan 1 Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, PAKISTAN Asad Abbas 2 University of Salmanca, SPAIN Mazhar Ayaz 3 Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, PAKISTAN Naeem Muhammad 4 Institute of Applied and Pure Biology, Bahauddin Zakariya University, Multan, PAKISTAN Saleem Qadir 5 University of Agriculture, Faisalabad, PAKISTAN Muhammad Saleem Akhter 6 Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, PAKISTAN Zia Waseem 7 Livestock and Dairy department, Government of Punjab, PAKISTAN P. Muthusamy 1 Department of Biotechnology, Karunya University,Tamil Nadu, INDIA S. Murugan 2 Department of Biotechnology, Karunya University,Tamil Nadu, INDIA Smitha Manothi 3 Department of Biotechnology, Karunya University,Tamil Nadu, INDIA Nishi K. 1 Department of Biology and Environmental Sciences, CSK Himachal Pradesh Krishi Vishwavidyalaya, Palampur, Himachal Pradesh, INDIA N.K. Gupta 2 Department of Biology and Environmental Sciences, CSK Himachal Pradesh Krishi Vishwavidyalaya, Palampur, Himachal Pradesh, INDIA S.C. Sharma 3 Department of Biology and Environmental Sciences, CSK Himachal Pradesh Krishi Vishwavidyalaya, Palampur, Himachal Pradesh, INDIA Kumar Praveen G.N. 1 Department of Biotechnology, Acharya Institute of Technology, Soladevanahalli, Bangalore-560 090, INDIA Sumangala K. Bhat 2 Department of Biotechnology, Acharya Institute of Technology, Soladevanahalli, Bangalore-560 090, INDIA Nacua Sherwin S. 1 Biology Department, Mindanao State University, Marawi City, PHILIPPINES Torres Mark Anthony J. 2 Department of Biological Sciences, MSU-Iligan Institute of Technology, 9200 Iligan City, PHILIPPINES Cesar G. Demayo 3 Department of Biological Sciences, MSU-Iligan Institute of Technology, 9200 Iligan City, PHILIPPINES Chaitra R. Hegde 1 Dept. of Microbiology, A Div. of Centre for Advanced Studies in Biosciences, Jain University, Bangalore, INDIA Madhuri M. 2 Dept. of Microbiology, A Div. of Centre for Advanced Studies in Biosciences, Jain University, Bangalore, INDIA Nishitha Swaroop T. 3 Dept. of Microbiology, A Div. of Centre for Advanced Studies in Biosciences, Jain University, Bangalore, INDIA Arijit Das 4 Dept. of Microbiology, A Div. of Centre for Advanced Studies in Biosciences, Jain University, Bangalore, INDIA Sourav Bhattacharya 5 Dept. of Microbiology, A Div. of Centre for Advanced Studies in Biosciences, Jain University, Bangalore, INDIA Rohit K.C. 6 Sapthagiri College of Engineering, Bangalore, INDIA Manju Junwal 1 Department of Zoology, Govt. Madhav Science College, Ujjain, MP, INDIA Ismail Bhai 2 Department of Zoology, Govt. Madhav Science College, Ujjain, MP, INDIA Jayshree Jatwa 1 Department of Zoology Govt. Madhav Science College Ujjain-456010 INDIA Ismail Bhai 2 Department of Zoology Govt. Madhav Science College Ujjain-456010 INDIA V. Verma 1 Presently Molecular Sciences and Nanotechnology, College of Eng. and Science, Louisiana Tech University, Ruston 71270 USA A. Bhardwaj 2 Department of Biotechnology, National Institute of Technology, Raipur-492010, INDIA S. Rathi 3 1Department of Biotechnology, National Institute of Technology, Raipur-492010, INDIA R.B. Raja 4 1Department of Biotechnology, National Institute of Technology, Raipur-492010, INDIA S. Balamuralitharan 1 Department of Mathematics, Sri Ramanujar Engineering College, Chennai-48, INDIA S. Rajasekaran 2 Department of Mathematics, B.S. Abdur Rahman University, Chennai-48, INDIA Rahman Khandkar-Siddikur 1 Forestry and Wood Technology Discipline, Khulna University, Khulna – 9208, BANGLADESH D.M. Nazmul Alam 2 Forestry and Wood Technology Discipline, Khulna University, Khulna – 9208, BANGLADESH Md. Nazrul Islam 3 JSPS Post Doctoral Fellow, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, JAPAN T.K. Bhatt 1 Department of Biotechnology, Central University of Rajasthan, Kishangarh, INDIA > Short Communication 2012 5 11 2012 June 10 Histone deacetylase (HDAC) is the key enzyme responsible for epigenetic regulation of an organism. This protein has been involved in transcriptional regulation of many proteins associated with chromatin remodelling. Homologs of histone deacetylase are also found in malaria parasite Plasmodium falciparum where it plays major role in regulation of key pathways of parasite. In this study, we determined the three-dimensional structure of histone deacetylase from Plasmodium falciparum (PfHDAC) by using homology modelling tools available at Swiss Modeller server and Modweb. Modelled structure was validated using Ramachandran plot and active site determination was performed using CASTp. We believe that structural analysis of PfHDAC could be pivotal in discovering new drug like molecules against malaria parasite. Copyright@ International Science Community Association