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Genotoxic effects of Mercuric Chloride in the Albino Rat, Rattus norvegicus

Author Affiliations

  • 1Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra, UP, INDIA

Res. J. Animal, Veterinary and Fishery Sci., Volume 2, Issue (7), Pages 6-9, July,24 (2014)


In the present study, toxicity of sublethal concentration of mercuric chloride on the karyotyping of Albino rat, Rattus norvegicus was observed, LD50 of mercury chloride was calculated and a sublethal concentration (1/20 LD50) was gives orally to the rat 20 hours prior to the colchicines treatment, 2 hours after this treatment the bone marrow was separated from the femur of test animal and collected in the test tube. The slide was prepared and studied under the microscope. The investigation reveals the numerical and structural aberrations in the chromosomes of the bone marrow cells in the test animal.


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