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Candida auris- threat to human healthcare facilities

Author Affiliations

  • 1Faculty of Department of Microbiology, Vijaygarh Jyotish Ray College (affiliated to the University of Calcutta), Kolkata, West Bengal, India

Res. J. Recent Sci., Volume 12, Issue (1), Pages 27-32, April,2 (2023)

Abstract

Candida auris is reported first as an emerging life threatening multidrug resistant pathogen in Japan, in 2009. Outbreak of this pathogen is usually nosocomial. Spread of this infection is of high concern as cases of transmission are found to take place despite implementation of enhanced infection prevention and control (IPC) measures. Different clinical manifestations of this multidrug resistant pathogen is from bloodstream infections (BSIs), deep-seated candidiasis, intra-abdominal candidiasis, to superficial infections occurring in patients, who are undergoing treatment for long period, specially to those who have lines or tubes entering their body, have central venous catheter or previously received antibiotics or antifungal medications. Epidemiological studies revealed sporadic distribution of C. auris in many countries worldwide. Evidences revealed about the genes and proteins involved in virulence and multidrug resistance in C. auris. Techniques to restrict the spread and possible controlling mechanisms required are recommended by ECDC and CDC. However, hospitals, even in developed countries also, are still not satisfactorily equipped to combat possible outbreak, because antifungal repertoire against C. auris is very limited. Therefore, further investigations in the field of disease epidemiology, therapeutics, immunology as well as molecular biology of C. auris are warranted.

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