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OncmiRs: Small Noncoding RNA with Multifaceted Role in Cancer

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Author Affiliations

  • 1 Interdisciplinary Research Centre, Department of Biotechnology, Malankara Catholic College, Mariagiri, Kaliakkavilai, TN, INDIA

Res. J. Recent Sci., Volume 1, Issue (11), Pages 70-76, November,2 (2012)

Abstract

Several advancements in cancer research occur till date and the involvement of miRNAs in cancer threw new hope to cancer therapy. OncomiRs are miRNAs which plays significant role in cancer. It serves as a double edged sword in cancer because up- regulation and down- regulation of miRNAs are observed in cancerous cells and hence acts as oncogenes and tumor suppressors respectively. Since, cancer is a disease affecting multiple cell types and with different stages, treatment of it remains as a biggest challenge. miRNA turns to be a promising therapeutic tool in cancer due to its regulatory role. This review briefs the multiple role of miRNA in cancer with special emphasis on tumor microenvironment, cell proliferation, angiogenesis, metastasis and apoptosis. Moreover the tumor suppressor and oncogenenic role of miRNAs are also discussed.

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