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Synthesis, Characterization, Antibacterial Activity and DNA cleavage studies of Schiff base Co(II) Transition Metal Complexes

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Author Affiliations

  • 1PG and Research Dept. of Chemistry, C. Abdul Hakeem College (Autonomous), Melvisharam-632509, Tamil Nadu, India

Res.J.chem.sci., Volume 6, Issue (2), Pages 1-9, February,18 (2016)

Abstract

Three Schiff base ligands L1, L2 and L3 were achieve by the condensation of o-phenylenediamine with p-methylbenzaldehyde, p-methoxybenzaldehyde and N-acetylthiourea respectively. Their complexes with Co(II) were prepared and characterized by elemental analyses, molar conductance, magnetic susceptibility, IR, UV-Vis spectra, NMR, Mass spectral studies, thermal behaviour and Powder X-ray diffraction studies have also been carried out. The IR data determine the bidentate coordination of L1, L2 and tetradentate coordination of L3. The XRD data show that Co(II) complexes with L1 , L2 and L3 have the crystallite sizes of 70, 72 and 78 nm respectively. The DNA cleavage activities of the Schiff base and its complexes were monitored by agarose gel electrophoresis method in the presence of hydrogen peroxide and the antibacterial activities of the ligand and complexes have also been carried out.

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