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TMSI-mediated Prins-type Reaction of Epoxides with Homoallylic Alcohols: Synthesis of Iodo-Substituted Tetrahydropyrans

Author Affiliations

  • 1Custom Pharmaceutical Services, Dr Reddy\'s Laboratories Limited, Bollaram Road, Miyapur, Hyderabad, 500049, India and Department of Organic Chemistry, Foods, Drugs and Water, Andhra University, Visakhapatnam, 530003, India
  • 2Ragas Pharmaceuticals Private Limited (OPC), IDA Cherlapally, Hyderabad, 500051, India
  • 3Custom Pharmaceutical Services, Dr Reddy\'s Laboratories Limited, Bollaram Road, Miyapur, Hyderabad, 500049, India
  • 4Department of Organic Chemistry, Foods, Drugs and Water, Andhra University, Visakhapatnam, 530003, India

Res.J.chem.sci., Volume 6, Issue (10), Pages 48-50, October,18 (2016)


The cyclization of epoxides with homoallylic alcohols in the presence of Trimethylsilyliodide generates the 4-iodo-tetrahydropyran derivatives in excellent yield.


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