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Design, Synthesis, Characterization and Biological Evaluation of Various N-substituted Piperazine Annulated s-Triazine Derivatives

Author Affiliations

  • 1Department of Chemistry, Sir P. T. Sarvajanik College of Science, Athwalines, Surat-395007, Gujarat, INDIA

Res.J.chem.sci., Volume 4, Issue (5), Pages 14-19, May,18 (2014)

Abstract

In an effort to discover new candidate, ten compounds were synthesized in a series of 2,4,6-trichloro-1,3,5-s-triazine analogues which in substitution with anisole, 4-hydroxy coumarin and different N-substituted piperazine derivatives on the C-6 position of s-triazine ring. The title compounds were screened for their in vitro antimicrobial activity against two gram-negative bacteria (E. coli, K. pneumoniae), two gram-positive bacteria (S. aureus, B. subtilis) and two fungal species (C. albicans and S. cerevisiae) using the disc diffusion method. Most of the synthesized compounds appeared with promising antimicrobial activity. The structure of the novel compounds were elucidated on the basis of IR, H NMR and elemental analysis.

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