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Synthesis and Antimicrobial Activity of some Salicylaldehyde Schiff bases of 2-aminopyridine

Author Affiliations

  • 1Department of Chemistry, Agra College, Agra, UP, INDIA
  • 2Department of Chemistry, B.K. Birla Institute of Engineering and Technology, Pilani, Rajasthan, INDIA

Res.J.chem.sci., Volume 3, Issue (9), Pages 26-29, September,18 (2013)


Schiff bases particularly (1) N-(2-hydroxylbenzylidene) pyridin-2-amine, (2) N-(5-nitro-2- hydroxylbenzylidene) pyridin-2-amine, (3) N-(5-bromo-2- hydroxylbenzylidene) pyridin-2-amine, (4) N- (5-methoxy-2-hydroxylbenzylidene) pyridin-2-amine are prepared from 2- aminopyridine and substituted benzyaldehydes. The synthesized compounds are characterized by elemental analysis, IR and HNMR. The result shows that the compounds are capable to prevent the growth of S. aureus and E. coli in diverse concentrations. The growth prevention capability was affected by the solvent and substitute group on the salicyldene part.


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