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Cinnamic acid Derivatives and 4-Aminoantipyrine Amides – Synthesis and Evaluation of Biological Properties

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Author Affiliations

  • 1 University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Pharmacy, Universitatii Street 16, 700115 Iasi, ROMANIA
  • 2 Institute of Macromolecular Chemistry of Romanian University, ”Petru Poni”, Grigore Ghica Voda Street 41, 700487 Iasi, ROMANIA

Res.J.chem.sci., Volume 3, Issue (3), Pages 9-13, March,18 (2013)

Abstract

Four new amides of cinnamic acid derivatives (cinnamic acid, p-coumaric acid, ferulic acid and caffeic acid) and 4-aminoantipyrine were synthesized and their structure was confirmed (1H-NMR, 13C-NMR, FTIR and elemental analysis). Some of their biological properties were evaluated: antimicrobial and antioxidant (DPPH radical scavenging activity, Fe3+reducing power). The tested compounds were more effective against Staphylococcus aureus than the corresponding free acids, but presented no effect on Gram negative bacteria and Candida albicans. The amides of caffeic and ferulic acid were very efficient antioxidants (DPPH radical scavenging assay: EC50 100 µM). The Fe3+ reducing power for the synthesized substances was similar or superior to that of the positive control (ascorbic acid).

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