Synthesis and Biological activities of some new Phthalides
Author Affiliations
- 1Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujrat, INDIA
- 2 School of Science and Education, Navrachana University, Vadodara-391410, Gujrat, INDIA
Res.J.chem.sci., Volume 2, Issue (8), Pages 57-61, August,18 (2012)
Abstract
A series of novel phthalide derivatives were prepared in one step, in moderate and good yields. The in vitro antibacterial and antifungal activities of these products were screened against two fungal strains (Thevialopsis paradoxa and Phomopsis mangiferae) and against bacterial strains (Staphylococcus aureus and Escherichia coli). The synthesized compounds were also tested for their analgesic and antioxidant activities. Structure activity relationship (SAR) reflects the effect of substituted phthalides on biological activity.
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