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Chemical Examination and Biological Studies on the Seeds of Psoralea Corylifolia Linn.

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Author Affiliations

  • 1Cavin Kare Research Centre, 12, Poonamalle Road, Ekkattuthangal Chennai 60032, INDIA

Res.J.chem.sci., Volume 2, Issue (1), Pages 50-58, January,18 (2012)

Abstract

The aim of the present investigation was to isolate chemical constituents and study of its biological activity from the seeds of acetone extract of Psoralea corylifolia Linn. The bio-assay guided isolation of acetone extract of seeds yielded five known compounds, -cadinene (1), bakuchiol (2), psoralen (3), isopsoralen (4) and psoralidin (5). The structures of these compounds were elucidated by physical and spectral data (UV, IR, H, 13C NMR and mass). The compound, -cadinene (1) is first report from this plant. Different extracts, fractions and compounds from the seeds were investigated for antimicrobial property. The methanolic, acetone and hexane extracts and isolated compound, bakuchiol (2) of Psoralea corylifolia were tested for antimicrobial studies against three gram positive bacteria and showed positive results. The compound bakuchiol (2) showed an excellent antibacterial activity than its crude extract.

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