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Exploring the synthesis, of transition metal complexes derived from 5-nitrosalicyaldehyde benzoylhydrazone characterization and their antimicrobial activities

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Author Affiliations

  • 1Federal University Dutsin-ma, Applied Chemistry, P.M.B 5001 Dutsin-ma, Katsina Nigeria
  • 2Federal University Dutsin-ma, Applied Chemistry, P.M.B 5001 Dutsin-ma, Katsina Nigeria

Res.J.chem.sci., Volume 13, Issue (3), Pages 27-32, October,18 (2023)

Abstract

Synthesis as well as Characterization of a Hydrazine derivative Schiff Base (L^) Derived from 5-Nitrosalicylaldehyde and Benzhydrazides, along with their transition divalent metal chelates of Ni, Cu, and Co. The complex ion were characterized using Melting Temperatures, FT-IR Spectrum Analysis, Magnetic Susceptibility, and UV-Vis Spectroscopy. These vibrant and stable ketimine and chelates remain undissolved in pure water but readily dissolve in organic solvents such as Dimethyl sulfoxide, acetone, and ethanol. The magnetic and spectral measurements suggest an octahedral geometry for the metal ions. The spectral data of the ligand displayed a prominent band at 1580c/m, confirming the presence of the imine group after synthesis. Interestingly, in the chelates, this peaks shifted to a higher spatial frequency, suggesting coordination of the imine nitrogen with the metal, thus establishing complexation through the N-atom of the imine moiety. The antimicrobial efficacy of the chelation compounds and ligating molecule was evaluated using the disc diffusion method against the bacterial isolates, namely Pseudomonas - aeruginosa, Enterobacter - cloacae, Klebsiella - pneumoniae, as well as Staphylococcus - aureus (G -ve and G +ve respectively), the fungi isolates, Aspergillus - niger as well as Phytopthera - infestans. Comparing the inhibitory effect of the analysis of the ligand (L1) and its respective chelate molecule demonstrated that the chelates displayed enhanced antimicrobial potency compared to the unbound ligand.

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