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Kinetic study and mechanistic elucidation for metformin oxidation by Mn(VII) in alkaline medium

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Author Affiliations

  • 1Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire-574 240, India
  • 2Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire-574 240, India
  • 3Post Graduate Department of Studies in Chemistry, Karnatak University, Dharwad-580 003, India

Res.J.chem.sci., Volume 12, Issue (2), Pages 53-63, June,18 (2022)

Abstract

The kinetics and oxidation of an anti-diabetic drug, metformin using permanganate in alkaline media was studied spectrophotometrically by keeping 0.01moldm-3ionic strength. The oxidation among permanganate with metformin in NaOH media shows 1:6 stoichiometry (metformin: permanganate). The oxidation reaction is first order dependence in [permanganate ion] and less than unit order in MET and hydroxyl ion concentrations, respectively. When ionic strength of reaction medium is increased, the rate of the reaction also increased. The consequence of dielectric constant of the media and externally added products were also studied. A proper mechanism for oxidation was proposed. The main product of the title reaction was recognized using LC-MS technique. The various constants of the reaction concerned in various steps in the mechanism were computed. The activation constants and thermodynamic values are also evaluated by graphical method and discussed in detail.

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