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Synthesis and Molecular Docking Studies of 3-Benzylidene-8- Methoxy-6-(prop-1enyl) Chroman-4-One Based Compound against Different HIV Receptors

Author Affiliations

  • 1Centre for Research and Development, PRIST University Thanjavur, Tamilnadu, INDIA
  • 2 Centre for Advanced computing and Bioinformatics, PRIST University Thanjavur, Tamilnadu, INDIA

Res. J. of Pharmaceutical Sci., Volume 1, Issue (3), Pages 6-9, November,30 (2012)


The Human Immunodeficiency Virus ( HIV) infection in human since last three decades is a tremendous issue in the area of infectious diseases. Currently plant based compounds are gaining more interest now-a-days in antiretroviral therpies. HIV replication is a target for the inhibition of HIV infection. The synthesized chroman-4-one based compound recognized as a antireplicative agent. With the synthesized crystals benzene and pyrone ring plays a major role ,molecular structure of the compounds were identified by subjecting the compound to X ray diffraction studies. Anti-HIV effects have been studied by different five viral Proteins. Ligand-protein molecular docking studies using advanced docking tools and minimum binding energies were computed. Comparison was made for better choice of protein ligand interaction


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