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Effect of Phyllanthus Urinaria in Biochemical Profile of Experimental Hyperglycemic Albino Rats

Author Affiliations

  • 1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, INDIA
  • 2 Vaish Institute of Pharmaceutical Education and Research, Rohtak-124001, Haryana, INDIA

Res. J. of Pharmaceutical Sci., Volume 1, Issue (1), Pages 2-5, September,30 (2012)


Phyllanthus urinaria is a widely used plant in the folklore medicines in several disorders due to its excellent properties and potent phytocontituents. The aim of this study was to evaluate the effect of pet ether, alcoholic and aqueous extracts of this plant in renal, liver and cardiovascular complications in alloxan-induced diabetic rats. The altered levels of biochemical parameters in diabetic animals as compared to normal indicating impaired metabolic functions were significantly improved by oral administration of Phyllanthus urinaria extracts at the dose of 0.5 g/kg once daily for a period of 21 days. Present study shows that alcoholic extract of Phyllanthus urinaria was found to be most effective which could possibly be due to the presence of potent phytoconstituents like tannins and flavonoids.


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