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Congenital Cytomegalovirus Infection Causing severe Inclusion Diseases in Infants - Case Report from Eastern India

Author Affiliations

  • 1ICMR Virus Unit, Kolkata, India
  • 2ICMR Virus Unit, Kolkata, India
  • 3ICMR Virus Unit, Kolkata, India
  • 4Dr. B.C. Roy post graduate institute of pediatric sciences, Kolkata, India
  • 5Dr. B.C. Roy post graduate institute of pediatric sciences, Kolkata, India
  • 6ICMR Virus Unit, Kolkata, India

Int. Res. J. Biological Sci., Volume 5, Issue (12), Pages 49-51, December,10 (2016)

Abstract

India currently faces a serious challenge to antagonize the increasing number of newborn deaths owing to Human Cytomegalovirus infection every year. Here in this study we report a severe case of congenital HCMV infection causing cytomegalic inclusion disease (CID) affecting the brain and CNS in an infant admitted to the neonatal care unit. This article represents the first documented case from India ascribing the severity of symptomatic congenital HCMV infection manifesting in the form of CID and highlighting the need for improved medical resources in a lower-middle income country like India to timely diagnose and combat this dreaded virus.

References

  1. Vanier T.M. (1960)., A case of cytomegalic inclusion disease., Thorax., 15, 259.
  2. Welle T.H. and Hanshaw J.B. (1962)., Virologic and clinical observations on cytomegalic inclusion disease., N Engl J Med., 266, 1233-1244.
  3. Chakravarty A., Kashyap B. and Rathi K. (2005)., The seroepidemiological study on cytomegalovirus in women of childbearing age with special reference to pregnancy and maternal-fetal transmission., Indian J Pathol Microbiol., 48, 518-521.
  4. Sheevani A., Jindal N. and Aggarwal A. (2005)., A pilot seroepidemiological study of cytomegalovirus infection in women of childbearing age., Indian J Med Microbiol, 23, 34-36.
  5. Boppana S.B., Pass R.F., Britt W.J., Stagno S. and Alford C.A. (1992)., Symptomatic congenital cytomegalovirus infection: neonatal morbidity and mortality., Pediatr Infect Dis J., 11, 93–99.
  6. Revello M.G. and Gerna G. (2002)., Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant.Clin Microbiol Rev,15,680-715, undefined
  7. Bissinger A.L., Sinzger C., Kaiserling E. and Jahn G. (2002)., Human cytomegalovirus as a direct pathogen: correlation of multiorgan involvement and cell distribution with clinical and pathological findings in a case of congenital inclusion disease., J Med Virol., 67, 200–206.
  8. Cheeran M.C., Lokensgard J.R. and Schleiss M.R. (2009)., Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention., Clin Microbiol Rev, 22(1),99-126.
  9. Gaytant M.A., Rours G.I., Steegers E.A., Galama J.M. and Semmekrot B.A. (2003)., Congenital cytomegalovirus infection after recurrent infection: case reports and review of the literature., Eur J Pediatr, 162, 248–253.
  10. Bale J.F., Miner L. and Petheram S.J. (2002)., Congenital Cytomegalovirus Infection., Curr Treat Options Neurol, 4(3), 225-230.
  11. Peckham C., Tookey P., Logan S. and Giaquinto C. (2001)., Screening options for prevention of congenital cytomegalovirus infection., J Med Screen, 8,119-124.