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Evaluation of Antimicrobial, Antioxidant and Cytotoxic Property of Pleurotus ostreatus Mushroom

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Author Affiliations

  • 1Department of Pharmacy, Southeast University, Banani, 1213, Dhaka, BANGALADESH
  • 2National Mushroom Development and Extension Center, Sobhanbag, Savar, Dhaka, BANGALADESH

Int. Res. J. Biological Sci., Volume 4, Issue (1), Pages 29-33, January,10 (2015)

Abstract

The study was conducted to estimate the performance of certain biological properties of oyster mushrooms (Pleurotus ostreatus). For determination of antimicrobial and cytotoxic activity of this mushroom disk diffusion technique and brine shrimp lethality bioassay were used. Ethyl acetate, hexane and chloroform extract were examined with ten test organism in which hexane extract showed higher antibacterial activity than chloroform and ethyl acetate for both gram positive and negative bacteria. The average zone of inhibition for hexane extract was in the range of 11-24mm. The total phenolic content ranged from 3.69 mg GAE/gm to 8.49 mg GAE/gm. In brine shrimp lethality bioassay LC50 values obtained were 10 ΅g/ml, 40 ΅g/ml and 75΅g/ml for hexane, ethyl acetate and chloroform, respectively. This study revealed that P. ostreatus mushroom has potential antimicrobial effect with significant antioxidant and anticancer activity.

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