International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Association between Plasma Cholesteryl Ester Transfer Protein activity and Lipid profiles in Metabolic Syndrome in an Iranian Population

Author Affiliations

  • 1Research Center for Molecular Medicine, Hamadan University of Medical Science, Hamadan, IRAN
  • 2 Department of Biochemistry and Nutrition, School of Medicine, Hamadan University of Medical Science, Hamadan, IRAN
  • 3v Department of Internal Medicine-Endocrinology, Medical School, Hamadan University of Medical Science, Hamadan, IRAN

Int. Res. J. Biological Sci., Volume 3, Issue (4), Pages 87-90, April,10 (2014)

Abstract

Metabolic syndrome (MS) is a predisposing factor for atherosclerosis, cardiovascular disease (CVD) and type 2 diabetes. Cholesteryl ester transfer protein (CETP) has a major role in the lipoproteins metabolism and subsequently lipid profile. This study was aimed to investigate possible relationship between plasma CETP activity and lipid profile in metabolic syndrome in a population from Iran. In this case-control study a total of 400 participants, 200 healthy individuals and 200 patients with metabolic syndrome were selected from residents of Hamadan city in western regions of Iran. A national Cholesterol Education Program guideline was used to diagnosis of MS. Blood sugar, lipid profile, and BMI were determined in all studied subjects. A fluorometric assay was used to measure the plasma CETP activity. Significant differences in lipid profile and waist circumference were observed between two studied groups (p=0.001). CETP activity was significantly higher (p0.001) in patients compared to normolipidaemic group. Correlation analysis showed an association between CETP activity and total cholesterol, LDL cholesterol, and HDL-C. Our results suggest that individual with MS has increased CETP activity. Augmented CETP activity and its association with reduction in HDL-C and increase in LDL-C indicate the important role of CETP in alteration of lipid profile and probably pathogenesis of MS.

References

  1. Timer O., Sisieter F. and Levey E., Metabolic syndrome X, A review, Can J Cardiol., 6, 779–89 (2000)
  2. Bloomgarden Z.T., Definitions of the insulin resistance syndrome: the 1st world congress on the insulin resistance syndrome, Diabetes Care, 27, 824–30 (2004)
  3. Alberti K.G., Zimmet P. and Shaw J., The metabolic syndrome—a new worldwide definition, Lancet, 366,1059–62 (2005)
  4. Grundy S.M. and Small L.D.L., atherogenic dyslipidemia, and the metabolic syndrome, Circulation, 95, 1– 4 (1997)
  5. Tall A., Plasma lipid transfer proteins, Annu Rev Biochem., 64, 235–257 (1995)
  6. Dedoussis G.V., Panagiotakos D.B., Louizou E. et al., Cholesteryl ester-transfer protein (CETP) polymorphism and the association of acute coronary syndromes by obesity status in Greek subjects: The CARDIO2000-GENE study, Hum Hered., 63, 155-161 (2007)
  7. Mohrschladt M.F., van der Sman-de Beer F., Hofman MK., et al. TaqIB polymorphism in CETP gene: The influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia, Eur J Hum Genet., 13, 877-882 (2005)
  8. Bruce C., Chouinard R.A. Jr., Tall A.R., Plasma lipid transfer proteins, high density lipoproteins, and reverse cholesterol transport, Annu Rev Nutr., 18, 297-330 (1998)
  9. Bruce C., Tall AR. Cholesteryl ester transfer proteins, reverse cholesterol transport, and atherosclerosis,Curr Opin Lipidol., , 306–311 (1995)
  10. Barter P.J. and Rye K.A., Molecular mechanisms of reverse cholesterol transport, Curr Opin Lipidol., , 82–87(1996)
  11. Franceschini G., Epidemiologic evidence for high-density lipoprotein cholesterol as a risk factor for coronary artery disease, Am J Cardiol., 88, 9N–13N (2001)
  12. 90Engl J Med., 323, 1234 –1238 (1990)
  13. Bathnagar D., Durrington P.N., Channon K.N., Prais H., Mackness M.I., Increased transfer of cholesteryl esters from high density lipoproteins to low density and very low density lipoproteins in patients with angiographic evidence of coronary artery disease, Atherosclerosis, 98, 25–32 (1993)
  14. Gue´rin M., Bruckert E., Dolphin P.J., Chapman M.J., Absence of cholesteryl ester transfer protein-mediated cholesteryl ester mass transfer from highdensity lipoprotein to low-density lipoprotein particles is a major feature of combined hyperlipidemia, Eur J Invest., 26, 485– 494 (1996)
  15. Yamashita S., Hui D.Y., Wetterau J.R., Sprecher D.L., Harmony J.A., Sakai N., Matsuzawa Y. and Tarui S., Characterization of plasma lipoproteins in patients heterozygous for human plasma cholesteryl ester transfer protein (CETP) deficiency: plasma CETP regulates high-density lipoprotein concentration and composition. Metabolism, 40, 756–763 (1991)
  16. Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III), Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP), JAMA,285, 2486-97 (2001)
  17. Grundy S.M., Brewer H.B., Cleeman J.I., Smith S.C., Lenfant C., Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition, Circulation, 109, 433-8 (2004)
  18. Akbarzadeh M., Hassanzadeh T., Saidijam M., Esmaeili R., Borzouei Sh., Hajilooi M., Mahjub H., Paoli M. Cholesteryl ester transfer protein (CETP) -629C/A polymorphism and it's effects on the serum lipid levels in metabolic syndrome patients, Mol Biol Rep., 39(10), 9529-34 (2012)
  19. Mooradian A.D., Haas M.J. and Wong N.C., Transcriptional control of apolipoprotein A-I gene expression in diabetes, Diabetes,53, 513–520 (2004)
  20. Tato F., Vega G.L. and Grundy S.M., Bimodal distribution of cholesteryl ester transfer protein activities in normotriglyceridemic men with low HDL cholesterol concentrations, Arterioscler Thromb Vasc Biol., 15, 446-51 (1995)
  21. Mann C.J., Yen F.T., Grant A.M., Bihain B.E., Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia, J Clin Invest., 88, 2059–66 (1991)
  22. Reilly M.P. and Rader D.J., The metabolic syndrome: more than the sum of its parts?, Circulation, 108, 1546–51 (2003)
  23. Sandhofer A., Kaser S., Ritsch A., Laimer M., Engl J., Paulweber B., et al. Cholesteryl ester transfer protein in metabolic syndrome, Obesity, 14, 812-8 (2006)
  24. Girard-Globa A., A polymorphism of the gene coding for cholesterol ester transfer protein (CETP) that affects transfer of plasma cholesterol ester and its sensitivity to regulation, Biomed Pharmacother, 51, 404-5 (1997)
  25. Aouizerat B.E., Allayee H., Cantor R.M., Dallinga–Thie G.M., Lanning C.D., de Bruin T.W., et al. Linkage of a candidate gene locus to familial combined hyperlipidemia, Lecithin: cholesterol acyltransferase on 16q, Arterioscler Thromb Vasc Biol., 19, 2730-6 (1999)
  26. Foger B., Ritsch A., Doblinger A., Wessels H., Patsch JR. Relationship of plasma cholesteryl ester transfer protein to HDL cholesterol: studies in normotriglyceridemia and moderate hypertriglyceridemia, Arterioscler Thromb Vasc Biol,.16, 1430–6 (1996)
  27. Ritsch A., Drexel H., Amann FW., Pfeifhofer C., Patsch JR. Deficiency of cholesteryl ester transfer protein: description of the molecular defect and the dissociation of cholesteryl ester and triglyceride transport in plasma, Arterioscler ThrombVasc Biol,. 17, 3433– 41 (1997)
  28. Sarmandal C.V. Cancer, heart and other chronic Diseases: Some preventive measures to control lipid peroxidation through choice of edible oils, I. Res. J. Biological Sci.,1(6), 68-75 (2012)
  29. Barter P.J., Brewer H.B. Jr., Chapman M.J. et al., Cholesteryl ester transfer trotein: A novel target for raising HDL and inhibiting atherosclerosis, Arterioscler Thromb Vasc Biol., 23(2), 160-7 (2003)
  30. Tall A., Plasma lipid transfer proteins. Annu Rev Biochem., 64, 235–257 (1995)