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The Role of Astrocytes in Alzheimer's disease

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Author Affiliations

  • 1Physiology discipline, Human Biology division, School of Medicine, International Medical University, Kuala Lumpur, Malaysia
  • 2Department of Anatomy, School of Medicine, Taylors University, Lakeside Campus, Selangor, Malaysia
  • 3Department of Preclinical Sciences, Faculty of Medicine and Health Sciences, University Tunku Abdul Rahman, Jalan Sungai Long, Bandar Sungai Long, Kajang, Selangor, Malaysia
  • 4Department of Preclinical Sciences, University Tunku Abdul Rahman, Faculty of Medicine, and Health Sciences, Jalan Sungai Long, Bandar Sungai Long, Kajang, Selangor, Malaysia
  • 5Anatomy discipline, Human Biology division, School of Medicine, International Medical University, Kuala Lumpur, Malaysia

Int. Res. J. Biological Sci., Volume 12, Issue (3), Pages 17-20, November,10 (2023)

Abstract

Alzheimer's disease (AD) is a neurodegenerative condition that impairs cognition, causes memory loss, and alters a person's behaviour and personality. The deposit of amyloid-β (Aβ) plaques and hyperphosphorylated tau, which results in neurofibrillary tangles, in the brain are two important pathogenic characteristics of AD. Numerous investigations have determined and confirmed that astrocytes in AD have both neurotoxic and neuroprotective properties. The unique pathophysiological mechanisms and roles of these cells remain unknown despite several explanatory theories. The review outlines the neuroprotective roles of astrocytes, like as inflammation control and Aβ elimination. It concludes by highlighting the intricate interactions that exist between astrocyte activities and AD pathogenesis. Research on reactive astrocytes' balance between neuroprotection and neurotoxicity is still ongoing. Although there is now no treatment for AD, a better understanding of these pathways and therapeutic approaches that target astrocytes may be the key to developing more potent therapies for this debilitating illness.

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