Possible Role of the Basal cells in Diagnostics of Oral Cancer

International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN. International E-Bulletin: Information/News regarding: Academics and Research

Possible Role of the Basal cells in Diagnostics of Oral Cancer

Author Affiliations

¹Department of Life Science, Assam University, Silchar 788011, Assam, INDIA Department of ENT, Silchar Medical College, Ghungoor, Silchar 788014, Assam, INDIA

Int. Res. J. Biological Sci., Volume 1, Issue (8), Pages 50-53, December,10 (2012)

Abstract

In India, oral cancer (OSCC) account for 30-40% cancers at all sites. In North-eastern India, where this study was conducted, tobacco related oral cancer is very common. High Mortality due to cancer can be decreased significantly if it detected and treated at the initial stage of the disease. The aim of this study was to assess cellular morphology in a group of patients with oral leukoplakia, erythroplakia and oral cancer measured by means of basal cell frequency in exfoliated buccal cells. The study is the first report on the changes in basal cells associated with oral cancer. The data strongly support a positive correlation between the basal cell level and malignization (changes from pre-malignant stage to cancer). It is suggested that the evaluation of frequency of basal cells in exfoliated buccal cells may be an additional criterion for establishing oral cancer risk and the study of basal cells in buccal smears will increase the sensitivity and specificity of cytology which could impact in diagnostics and secondary prevention of oral cancer.

References

Hulka B.S., Wilcosky T.C. and Griffith J.D., Biological markers in epidemiology, Oxford Univ. Press, New York (USA), 38–75 (1990)
Bonassi S., Neri M., Lando C., Ceppi M., Lin Y-P., Chang W. P., Holland N., Kirsch-Volders M., Zeiger E. and Fenech M., Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project, Mutat. Res.,77, 1–12 (2003)
Celik A. and Kanik A., Genotoxicity of occupational exposure to wood dust: micronucleus frequency and nuclear changes in exfoliated buccal cells, Environ. Mol. Mutagen.,47, 693–698 (2006)
Kausar A., Giri S., Mazumdar M., Giri A., Roy P. and Dhar P., Micronucleus and other nuclear abnormalities among betel quid chewers with or without sadagura, a unique smokeless tobacco preparation, in a population from North-East India, Mutat. Res.,677(1-2), 72–75 (2009)
Mehrotra R., Gupta A., Singh M., and Ibrahim R., Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions, Mol. Cancer, 11 (2006)
Veiro J.A. and Cummins P.G., Imaging of skin epidermis from various origins using confocal laser scanning microscopy, Dermatology,189, 16–22 (1994)
Thomas P., Hecker J., Faunt J. and Fenech M., Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease, Mutagenesis , 22(6), 371–379 (2007)
Belien J.A., Copper M.P., Braakhuis B.J., Snow G.B. and Baak J.P., Standardization of counting micronuclei: definition of a protocol to measure genotoxic damage in human exfoliated cells, Carcinogenesis, 16, 2395-2400 (1995)
Perrotte P., Matsumoto T., Inoue K., Kuniyasu H., Eve B.Y., Hicklin, D.J., Rainsky R. and Dinney C.P., Anti-epiermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nue mice, Clin Cancer Res.,, 257-265 (1999)
Lowe H. I.C., Watson C. T., Badal S., Ateh E. N., Toyang N.J. and Bryant J. Anti-angiogenic properties of the Jamaican ball moss, (Tillandsia recurvata L.), I.Res. J. Biological Sci.1(4), 73-76, (2012)
Rich A.M., Nataatmadja M.I. and Reade P.C., Basal cell nuclear size in experimental oral mucosal carcinogenesis, Br. J. Cancer, 64, 96–98 (I991)
Drill V.A., Interrelationship between thyroid function and vitamin metabolism, Physial. Rev., 23, 355-379 (1943)
Brandwein-Gensler M., Teixeira M.S.; Lewis C.M., Lee B., Rolnitzky L., Hille J.J., Genden E., Urken M.L. and Wang B.Y., Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival, Am. J. Surg. Pathol., 29, 167–178 (2005)
Aweng E.R., Nur H., Mohd Nawi. M.A., Nurhanan Murni. Y., and Shamsul M. Antioxidant Activity and Phenolic Compounds of VitexTrifolia Var,Simplicifolia Associated with Anticancer, ISCA J. BiologicalSci., 1(3), 65-68, (2012)

[ref1] Hulka B.S., Wilcosky T.C. and Griffith J.D., Biological markers in epidemiology, Oxford Univ. Press, New York (USA), 38–75 (1990)

[ref2] Bonassi S., Neri M., Lando C., Ceppi M., Lin Y-P., Chang W. P., Holland N., Kirsch-Volders M., Zeiger E. and Fenech M., Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project, Mutat. Res.,77, 1–12 (2003)

[ref3] Celik A. and Kanik A., Genotoxicity of occupational exposure to wood dust: micronucleus frequency and nuclear changes in exfoliated buccal cells, Environ. Mol. Mutagen.,47, 693–698 (2006)

[ref4] Kausar A., Giri S., Mazumdar M., Giri A., Roy P. and Dhar P., Micronucleus and other nuclear abnormalities among betel quid chewers with or without sadagura, a unique smokeless tobacco preparation, in a population from North-East India, Mutat. Res.,677(1-2), 72–75 (2009)

[ref5] Mehrotra R., Gupta A., Singh M., and Ibrahim R., Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions, Mol. Cancer, 11 (2006)

[ref6] Veiro J.A. and Cummins P.G., Imaging of skin epidermis from various origins using confocal laser scanning microscopy, Dermatology,189, 16–22 (1994)

[ref7] Thomas P., Hecker J., Faunt J. and Fenech M., Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease, Mutagenesis , 22(6), 371–379 (2007)

[ref8] Belien J.A., Copper M.P., Braakhuis B.J., Snow G.B. and Baak J.P., Standardization of counting micronuclei: definition of a protocol to measure genotoxic damage in human exfoliated cells, Carcinogenesis, 16, 2395-2400 (1995)

[ref9] Perrotte P., Matsumoto T., Inoue K., Kuniyasu H., Eve B.Y., Hicklin, D.J., Rainsky R. and Dinney C.P., Anti-epiermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nue mice, Clin Cancer Res.,, 257-265 (1999)

[ref10] Lowe H. I.C., Watson C. T., Badal S., Ateh E. N., Toyang N.J. and Bryant J. Anti-angiogenic properties of the Jamaican ball moss, (Tillandsia recurvata L.), I.Res. J. Biological Sci.1(4), 73-76, (2012)

[ref11] Rich A.M., Nataatmadja M.I. and Reade P.C., Basal cell nuclear size in experimental oral mucosal carcinogenesis, Br. J. Cancer, 64, 96–98 (I991)

[ref11] Drill V.A., Interrelationship between thyroid function and vitamin metabolism, Physial. Rev., 23, 355-379 (1943)

[ref12] Brandwein-Gensler M., Teixeira M.S.; Lewis C.M., Lee B., Rolnitzky L., Hille J.J., Genden E., Urken M.L. and Wang B.Y., Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival, Am. J. Surg. Pathol., 29, 167–178 (2005)

[ref13] Aweng E.R., Nur H., Mohd Nawi. M.A., Nurhanan Murni. Y., and Shamsul M. Antioxidant Activity and Phenolic Compounds of VitexTrifolia Var,Simplicifolia Associated with Anticancer, ISCA J. BiologicalSci., 1(3), 65-68, (2012)